Projects

 

ducks The KressWorks Institute is working to find a real solution to cancer. We are working with chromosomal translocations and developing a patient specific methodology that will give cancer patients more options, more control, and a better chance at a long, healthy life.

A Patient Specific Methodology for the Treatment of Ewing Sarcoma

Our primary project is the development of a patient specific methodology for the systematic treatment of Ewing Sarcoma.

This methodology will be extensible to the treatment of many other forms of cancer and other diseases.

Chromosomal Translocations

In addition to our chief goal of developing a patient specific methodology for the treatment of Ewing Sarcoma, our researchers are also investigating Chromosomal Translocations.

Chromosomal Translocations play a key role in Ewing Sarcoma and a major role in the beginnings of many other forms of Cancer. In genetics, a chromosome translocation is a chromosome abnormality caused by rearrangement of parts between nonhomologous chromosomes. A gene fusion may be created when the translocation joins two otherwise separated genes, the occurrence of which is common in cancers, including Ewing Sarcoma.

Unfortunately, this phenomena is not well understood at the molecular level. It appears to be correlated with islanding of Cytosine-Guanine paired nucleotides connected along the DNA backbone. We are performing detailed atomistic and molecular calculations of DNA segments in which we simulate this islanding (plus other combinations of nucleotides) in an effort to better understand the fundamental principles involved in DNA double strand breakage, chromosomal fragment transport within the nucleus and subsequent chromosomal fragment fusion.

* The National Cancer Institute (NCI) dedicates approximately 4% percent of its annual budget to childhood cancer research. This means children are dying each and every day while new child specific treatments flounder in the idea stage due to a definitive lack of funding. 

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