The KressWorks Institute is working to find a real solution to cancer. We are working with chromosomal translocations and developing a patient specific methodology that will give cancer patients more options, more control, and a better chance at a long, healthy life.
Our primary project is the development of a patient specific methodology for the systematic treatment of Ewing Sarcoma.
In addition to our chief goal of developing a patient specific methodology for the treatment of Ewing Sarcoma, our researchers are also investigating Chromosomal Translocations.
Understanding Atomistic Level Properties of DNA
We will be performing Molecular Dynamics calculations on multiple oligomers of DNA. The oligomers will consist of multiple combinations of nucleotides. For various snapshots of simulated systems, we will perform QM/MM calculations which will provide us with the detailed atomistic information that will allow us to determine the nature of the structural properties of, and reactive sites on the DNA.
Systematic Treatment Method for Ewing Sarcoma
Our Research Objective will be to converge Science, Mathematics & Engineering via Systems Engineering. We will use that converged knowledge to develop a prototypical Targeted, Effective and Efficient Systematic Treatment Methodology (STM) for Ewing Sarcoma.
Integrated Network Analysis of Ewing Sarcoma
Our Research Objective will be to develop an integrated, detailed, systemic mechanistic computational representation of Ewing Sarcoma (ES) using the HoC as an overall guide to more fully understand the disease by including the spectrum of –omics technologies. No such system level, integrated representation of Ewing Sarcoma currently exists. Current research is focused on individual details of how Ewing’s responds to a specific treatment or how specific entities are implicated in portions of the disease genotype, heterogeneity, phenotype or progression. However, no systemic focus is provided nor are these individual details translated into the systemic representation which is required to systematically & comprehensively diagnose, monitor, & treat ES.
Structure of EWS-FLI1 and How It Attacks DNA
Our Research Objective will be to determine a structure for the EWS-FLI1 oncoprotein and characterize its binding to DNA.